Caroline Labrune, Fictions dramatiques et succession monarchique (1637-1691)

Dmd065110 1691..1701

The clinical efficacy of anthracyclines (e.g., doxorubicin and daunorubicin) in cancer therapy is limited by their severe cardiotoxicity, the etiology of which is still not fully understood. The development of anthracycline-induced cardiomyopathy has been found to correlate with myocardial formation and accumulation of anthracycline secondary alcohol metabolites (e.g., doxorubicinol and daunoru...

Finding truth in fictions: identifying non-fictions in imaginary cracks

I critically examine some recent work on the philosophy of scientific fictions, focusing on the work of Winsberg. By considering two case studies in fracture mechanics, the strip yield model and the imaginary crack method, I argue that his reliance upon the social norms associated with an element of a model forces him to remain silent whenever those norms fail to clearly match the characteristi...

Laboratory Fictions

Richard Morton (1637-1698).

RICHARD MORTON, the first physician since Galen to envisage a concept of the unity of tuberculosis and the first physician ever to state that tubercles are always present in its pulmonary form, was born in the county of Suffolk and baptised on 30 July 1637 in the parish of Ribbesford, Worcestershire, where his father, Robert Morton, was minister of Bewdley Chapel from 1635 to 1646. Richard Mort...

C0lc00577k 1629..1637

An optical tweezers directed parallel DNA oligonucleotide synthesis methodology is described in which controlled pore glass (CPG) beads act as solid substrates in a two-stream microfluidic reactor. The reactor contains two parallel sets of physical confinement features that retain beads in the reagent stream for synthetic reaction but allow the beads to be optically trapped and transferred betw...